Medicine isnt about saving lives anymore. Compulsive hand washing? But a panel of key opinion leaders from the NIH, CDC . The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". Completely avoid caffeine, alcohol, tylenol, and benadryl. Dosage there is 30mg once a day. Im just telling you the truth. Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. The NIH wrote a bullshit rejection because the FDA told them not to approve it. In short, a lot of mumbo jumbo. I wanted to get the article out before my flight left. There are other non-prescription things you should always have on hand. The NIH never did a risk benefit analysis of this drug. How can we get fluvoxamine? Jeffrey Morris, director of biostatistics at the University of Pennsylvania Perelman School of Medicine, has made debunking Kirschs claims something of a hobby. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. In some cases, youd want to taper down the dosage. Doctors have no excuse for not prescribing. The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. In two trials (both published studies in peer reviewed journals with Editor's Choice in both cases), the drug had a 100% effect size in protecting against hospitalization from the respiratory symptoms from COVID. more time. Steve Kirsch. Waiting months for the phase 3 trial to complete is nuts. I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. Steve Kirsch Executive Director at COVID-19 Early Treatment Fund (2020-present) Author has 176 answers and 1.7M answer views Updated 1 y Both. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. It works best when it is given early, as soon as symptoms start. I have all of these on hand and I load up on vitamin D3 every day. Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). Paper reviewing the evidence and mechanisms of action for fluvoxamine: Lenze Phase 2 RCT published Nov 12, 2020: Seftel RWE trial that confirmed the Phase 2 trial published Feb 1, 2021. We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. (Siliciano did not respond to requests for comment for this article.). skirsch.io Steve Kirsch Home page. It has shown to be 100% protective of hospitalization in 2 clinical trials. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls.. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Doctors who are most familiar with the drug would prescribe it to their patients. . And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. The infectious disease scientists lied to me. This is a more comprehensive look at the key evidence supporting fluvoxamine: Hear from the doctors who did the studies directly as well as the Dean of Medicine at Emory University: List of the best evidence-based COVID treatment options. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. We should not wait for the Phase 3 RCT. $1M reward: Do we need more data re: Fluvoxamine for COVID-19? Fluvoxamine is a very safe drug on market for 37 years, tens of millions of people have taken it, no record in scientific literature of anyone dying on overdose, and according to doctors that know the drug the best, about as dangerous as taking a Tylenol. He told me that while he and his family got vaccinated as soon as they were eligible, he got the idea that vaccines are dangerous from a man he hired to clean his carpets, who got very sick after receiving the vaccine. Then he hosted a superspreader event. To date, we have heard nothing suggesting the drug doesn't work or could be harmful. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). NIH is still unsure whether fluvoxamine should be used to treat COVID. . That was a lie. The babys brain was split in half, and it was just covered with blood. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. Its motivated out of his sense of keeping people safe and advancing health care.. Fluvoxamine is the poster child of the COVID-19 Early Treatment Fund (CETF). Indeed, some of the most prominent people spreading misinformation about ivermectin and vaccines today began by promoting hydroxychloroquineincluding by claiming to debunk Boulwares data analysis. My favorite dosage is 50mg twice a day for 14 days. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). See this. . The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. That study was featured on 60 Minutes. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here. Here are the key things you should know about fluvoxamine for COVID: It works. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? We look for advances that will have a big impact on our lives and break down why they matter. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. The medical community did nothing (with a few exceptions like Dr. Seftel). Now they turn to Rust. Please, As of November 13, fluvoxamine has been proven to work in every trial that has published results, including, studies. That trial has now been completed, and the researchers are analyzing their data. Almost 2.5 million people signed up to Dr. B with the promise of getting leftover vaccines. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. It could do nothing. Compulsive fiddling with your mask? . Once the Phase 2 result came out, it should have been embraced by doctors. I will . MisinformationKills. This is what the Seftel trial at Golden Gate fields used. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. Mar. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. I couldnt tell I was on the drug. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. Still, in the moment, his question threw me, and I stuttered. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. Here are my answers. I couldnt tell I was on the drug. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. So why would we wait when lives are being lost? Here is the latest version. iRobot said it had consent to collect this kind of data from inside homesbut participants say otherwise. Online. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. Doctors who have used fluvoxamine in the US and other countries swear by it. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. If you have trouble getting a prescription, perhaps you have OCD? . Or just depression about the vaccine mandates? He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. In other cases, stop cold turkey. Last Checked: 03/02/2023. So it was both obvious and convincing the difference between the groups to the workers and the track management. The next major effect is that that fluvoxamine activates the sigma-1 receptor. My crime? You cannot get any better than that. Everyone says "we need more data" to show fluvoxamine works for COVID. Dosing. This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. People who report not tolerating the drug are typically prescribed too high a dose. He may not be a good scientist, but hes smart, says WVUs Feinberg. The track management was so impressed, they asked for prescriptions. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. customer-service@technologyreview.com with a list of newsletters youd like to receive. Download Citation | On Mar 1, 2023, Gne Seda Albayrak and others published A Cross-Sectional Study on the Personality Traits of Episodic and Chronic Migraine Patients | Find, read and cite all . He has been a medical philanthropist for more than 20 years. Eventually, a press representative who was listening in, David Satterfield, unmuted his microphone to suggest we finish our conversation by email. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. The rest of the board soon followed. That work has yielded one promising candidate, the antidepressant fluvoxamine; other CETF-funded efforts have been less successful. No long haul symptoms if you start the drug ASAP after first symptoms. Silence from the medical community. All the supporting observational studies were positive as well. In-patient use. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here.. S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease. Get your prescription in advance of getting COVID. This looks ominous, but it harmless. It is not unusual to be wary of developing science, or wrong to be skeptical of pharmaceutical companies. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. Most doctors wont use it until NIH greenlights it, no matter what the science says. Skirsch.io Steve Kirsch Home page Fluvoxamine, COVID, pandemic, . After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. No long haul symptoms if you start the drug ASAP after first symptoms. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. Don't underestimate the virus. Medicine today isnt about saving your life. There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. Compulsive fiddling with your mask? reach out to us at Another is to identify an asteroid that is going to hit the planet.. The medical community did nothing (with a few exceptions like Dr. Seftel). just like ivermectin). They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. The medical community doesnt care about saving lives. 90,000 people will die in the next 3 weeks alone if we continue to ignore this drug that has caused no harm. Keeping this drug off the NIH Guidelines does nothing to reduce the death rate. All the medical journals refused to publish the meeting notes (rejected by 6 journals). . Ive used it personally at 50mg twice a day and experience no adverse events at all. Has it really been 25 years, a whole quarter of a century? Steve Kirsch said scientists and clinicians are studying a host of drugs and therapeutics to create a new line of defence against the virus but clinical trials are yet to lead to conclusive. Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. If you start 5 days after symptoms, all bets are off. Lack of action. P-value was 10^-14 on that study (done by Dr. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Compulsive hand washing? I learned this the hard way. Once the Phase 2 result came out, it should have been embraced by doctors. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. . Read More fluvoxamine The Fluvoxamine FAQ The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process. . Fluvoxamine was reportedly added to just 2 practice guidelines (Ontario and Johns Hopkins). Their willingness to lie did. My website www.skirsch.io has tons of info on fluvoxamine with all the links. Kirsch and his wife, Michele, fund a charitable foundation, which by 2007 had given $75 million to different causes. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. Fluvoxamine has a 40 year safety track record. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. JAMA systematic review and meta analysis It doesnt get any better than this. P-value was 10^-14 on that study (done by Dr. Seftel). He prefers iconoclastic approaches, whether by directly funding asteroid detection or advocating for nuclear power to combat global warming. A very short op-ed arguing for using fluvoxamine against COVID. I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. This advice is now outdated. For example all of these combos should have near 100% success against hospitalization, death, and long-haul COVID symptoms: Proxalutamide and fluvoxamine I took it myself at that dosage and noticed zero side effects. Who knows, Morris replied. The reason is pure corruption. Be warned!. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. Over the last 18 months, the fund has granted at least $4.5 million to researchers testing the covid-fighting powers of drugs that are already FDA-approved for other diseases. During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. If not, they should at least acknowledge that fluvoxamine might be helpful by at least listing it as a possibility. We are ignoring the advice of the KOL group and doing nothing. While he declined a phone interview, Boulware was recently the subject of a Mother Jones article about the harassment hes received for his research on hydroxychloroquine and ivermectin. May 16, 2022. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora Its all about NIH saying it is OK. Medicine today is driven by government opinion, not science. , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. While YouTube has repeatedly taken down the full video of the DarkHorse episode, various clips have been watched over 4 million times, and the full audio remains available on Spotify. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls, she said. All can merit a fluvoxamine prescription based on traditional diagnoses. It cant be more clear than this. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. Thanks for working tirelessly to help others. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. Sage Hana. this is NOT about the science. He's founded 7 companies, 2 with billion dollar valuations. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. Fluvoxamine (Luvox) is a Selective Serotonin Receptor Inhibitor (SSRI) that is clinically indicated for OCD in children, and can be used off label for depression. Its really, really common for a small effect, something that looks exciting, to be a statistical fluke when you look at a larger population. You can use fluoxetine as well (aka Prozac). Steve Kirsch's Newsletter ^ | 02/26/22 | Steve Kirsch. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. I disagree with his interpretation of the data regarding several medicines and strongly disagree with his anti-vaccine nonsense, Boulware wrote to me. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. And FrameMaker is still a niche product. Dose escalation studies in lupus patients and in rheumatoid arthritis patients established that 800 mg per day for life and 1,200 mg per day for 6 weeks are extremely well-tolerated. Please. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. Instead, it erodes confidence in our government to provide timely advice that is in the public interest. A few months ago, Kirsch suddenly stopped promoting hydroxychloroquineeven scrubbing it from the CETFs official list of trials it has funded. It does not matter how many lives will be saved. Steve angrily decried this development as more evidence of FDA corruption. A very short op-ed arguing for using fluvoxamine against COVID. ). Dr. Joe Ladapo wrote a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients." This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. CETF founder Steve Kirsch accepted an invitation to discuss the findings on a weekly . Weve known it works since August 24, 2020. So probability of successful Phase 3 can be estimated to be over 99.99% since there are tens of thousands of phase 3 studies. just like ivermectin). 1 hr ago. As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. (Clayton Fox, Marty Makary, and Jeffrey Klausner). The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. But fear of trying something new prevents any doctor from giving this drug a try. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. So much for evidence-based medicine. The choice couldn't be more clear cut. One of the first CETF grants was to investigate the antimalarial hydroxychloroquine. By Steve Kirsch in fluvoxamine Feb 14, 2021 The case for fluvoxamine for treating COVID-19 A very short op-ed arguing for using fluvoxamine against COVID. The US government accused Janssen of improperly promoting the antipsychotic drug Risperdal to dementia patients despite the drug increasing deaths in the elderly. After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. Most doctors wont use it until NIH greenlights it, no matter what the science says. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. They left their recommendation of fluvoxamine at NEUTRAL. Avoid caffeine, benadryl, tylenol, and alcohol. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. Quick Summary . The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir!

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